主要研究领域 

    聚焦T细胞和巨噬细胞抗感染抗肿瘤的新机制，在Immunity、Nat Immunol、J Exp Med、PNAS、Trends Cell Biol等发表约50篇文章。近年77779193永利以通讯作者，发表20多篇论文，包括2篇Immunity、Sci Adv、PNAS； 3篇Cell Reports；及Nat Microbiol、J Clin Invest、J Exp Med、Cell Research、EMBO Mol Med等。应邀在2014年77779193永利美国冷泉港大会、2015年77779193永利欧洲免疫学大会、2016年77779193永利美国免疫学大会、2017年77779193永利苏州冷泉港、多届海峡两岸四地免疫学探讨会、新加坡AStar、清华大学免疫所和上海交大免疫所等国内外会议和大学作学术报告。多次应邀作为基金委优青、重点、联合基金、面青地等项目；科技部项目&上海市科委项目的会评专家。

奖励或荣誉

2020年77779193永利国家百千万人才“有突出贡献中青年77779193永利专家”

2019年77779193永利上海市巾帼建功标兵

2018年77779193永利国家杰出青年77779193永利科学基金

2014年77779193永利国家优秀青年77779193永利科学基金

2015年77779193永利中科院优秀研究生指导教师

2011年77779193永利获中国科学院“百人计划” & 2011年77779193永利上海“浦江人才计划”

2009年77779193永利英国免疫学会旅行奖

2008年77779193永利美国Keystone大会旅行奖

2007年77779193永利英国剑桥大学CIMR年77779193永利会墙报一等奖

2006年77779193永利第13届全英华人生命科学大会墙报一等奖

科研项目：

1. 2019年77779193永利国家基金委重点项目，胆固醇代谢调控巨噬细胞抗感染抗肿瘤，主持人
2. 2018年77779193永利国家基金委“杰出青年77779193永利”项目，免疫细胞调控炎症相关疾病，主持人
3. 科技部重大科学研究项目，动物流感病毒遗传变异与致病机理研究，2016YFD00200，2016年77779193永利-2020年77779193永利，课题组长
4. 中科院先导B项目“细胞命运可塑性的分子基础和调控”，XDB19000000，2016年77779193永利-2020年77779193永利，课题组长
5. 科技部重大科学研究项目，应激对组织器官代谢稳态和发育的调控作用和机制，2018YFA0800700，2019年77779193永利-2024年77779193永利，学术骨干

1. Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nat Neurosci. 2022 May;25(5):577-587. doi: 10.1038/s41593-022-01063-z. Epub 2022 May 6. PMID: 35524140.
2. Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H. AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. EMBO J. 2022 Mar 15;41(6):e108016. doi: 10.15252/embj.2021108016. Epub 2022 Feb 22. PMID: 35191555; PMCID: PMC8922272.
3. Ma L, Li W, Zhang Y, Qi L, Zhao Q, Li N, Lu Y, Zhang L, Zhou F, Wu Y, He Y, Yu H, He Y, Wei B, Wang H. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2022 Jun;18(6):1385-1400. doi: 10.1080/15548627.2021.1985338. Epub 2021 Oct 10. PMID: 34632918; PMCID: PMC9225223.
4. Zhang C, Li W, Lei X, Xie Z, Qi L, Wang H, Xiao X, Xiao J, Zheng Y, Dong C, Zheng X, Chen S, Chen J, Sun B, Qin J, Zhai Q, Li J, Wei B, Wang J, Wang H. Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity. Sci Adv. 2021 Sep 17;7(38):eabb5933. doi: 10.1126/sciadv.abb5933. Epub 2021 Sep 17. PMID: 34533996; PMCID: PMC8448453.
5. Zhang F*, Qi L*, Feng Q, Zhang B, Li X, Liu C, Li W, Liu Q, Yang D, Yin Y, Peng C, Wu H, Tang ZH, Zhou X, Xiang Z, Zhang Z, Wang H#, Wei B#. HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis. PNAS. 2021;118(28):e2021798118. doi: 10.1073/pnas.2021798118. PMID: 34244427.
6. ZQ Li^1*, J Xiao^*, XY Xu^*, WY Li^*, RY Zhong, LL Qi, JH Chen, GZ Cui, S Wang, YX Zheng, Y Qiu, S Li, X Zhou, Y Lu, JY Lyu, B Zhou, JW Zhou, NH Jing, B Wei#, J Hu#, H Wang#. M-CSF, IL-6, and TGF-βb promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery. Science Advances, 2021;7:eabb6260
7. J Xiao^*, WY Li^*, X Zheng, L Qi, H Wang, C Zhang, XP Wan, YX Zheng, RY Zhong, X Zhou, Y Lu, ZQ Li, Y Qiu, C Liu, F Zhang, YB Zhang, XY Xu, ZZ Yang, HL Chen, QW Zhai, B Wei#, H Wang#, Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. Immunity, 2020, 52: 1-14 (Immunity, 同行评述)
8. C Liu, XY Xu, L Han, XP Wan, LM Zheng, CY Li, J Xiao, RY Zhong, X Zheng, Q Wang, HL Chen, B Wei#, H Wang#, LRCH1 deficiency enhances LAT signalosome formation and CD8⁺ T cell responses against tumor and pathogens. PNAS 2020;117(32):19388-19398
9. Q Wang^*, X Zhou^*, L Yang^*, YJ Zhao, ZH Chew, J Xiao, C Liu, X Zheng, YX Zheng, Q Shi^,, QQ Liang^#, YJ Wang^#*, H Wang^#. The natural compound Notopterol binds and targets JAK2/3 to ameliorate inflammation and arthritis. Cell Reports 2020;32:108158
10. Y Lu^*, Y Qiu^*, P Chen, H Chang, L Guo, F Zhang, L Ma, C Zhang, X Zheng, J Xiao, R Zhong, L Han, X Xu, Y Zhang, D Li, G Zhong, R Boyton, Y Huang, Y He, R Hu^#, B Wei^#, H Wang^# The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology, 2019,4:2331-46
11. X Zhou, WY Li S Wang, P Zhang, Q Wang, J Xiao, C Zhang, X Zheng, X Xu, S Xue, L Hui, H Ji, B Wei#, H Wang#. YAP aggravates inflammatory bowel disease (IBD) via regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Reports, 2019, 27;1176-89 
12. T Zhou#, MC Luo^*, W Cai, SY Zhou, DY Feng, CD Xu, H. Wang#. Runt-related transcription factor 1 (RUNX1) promotes TGF-β-induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K subunit p110δ. EBioMedicine, 2018.31:217-225
13. Q Wang^*, X Zhou^*, YJ Zhao, J Xiao, Y Lu, Q Shi, YJ Wang#, H. Wang#, QQ Liang#. Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-kB Pathway. Frontiers in Immunology, 2018.9: article 2091.
14. XY Xu^*, L Han^*, G. Zhao, SJ Xue, Y Gao, J Xiao, ZY Wu, JP Ding, B Wei, RG Hu, H Wang. LRCH1 interferes with DOCK8-Cdc42 module-induced T cell migration and ameliorates multiple sclerosis. J Exp Med, 2017; 214(1):209-226.
15. SJ Xue^*, C Liu^*, XJ Sun, WY Li, C Zhang, X Zhou, Y Lu, J Xiao, CY Li, XY Xu, B Sun, GL Xu, H Wang. TET3 inhibits IFN-I production independent of DNA demethylation. Cell Reports, 2016;16:1-10
16. Luo MC^*, Zhou SY^*, Feng DY, Xiao J, Li WY, Xu CD, Wang HY#, Zhou T#. Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock. J Biol Chem. 2016;291 (42), 22011-22020.
17. WY Li^*, J Xiao^*, X Zhou, M Xu, C Hu, X Xu, Y Lu, CLiu, S Xue, LNie, H Zhang, ZLi, Y Zhang, F Ji, L Hui, W Tao, B Wei# and H Wang#, STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma. J Clin Invest, 2015; 125(11):4239-54
18. Li C, Li W, Xiao J, Jiao S, Sheng C, Rudd CE, Wei B#, Wang H#. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8⁺ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Molecular Medicine, 2015: e201404578
19. Li C^*, Jiao S^*, Wang G, Gao Y, He X, Liu C, Zhang G, Wei B, Chen H#, Wang H#. The immune adaptor ADAP regulates reciprocal TGF-b1-integrin crosstalk to protect from H5N1 influenza virus infection. PLoS Pathogens, 2015, 11(4):e1004824
20. Fu X^*, Xiao J^*, Wei Y, Guo H, Li S, Liu Y, Yin J, Li D, Wang H#, Hu P#. Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro. Cell Research, 2015, 25:655-73 (Cover Story)
21. Zhang Y^*, Lu Y^*, Ma L, Jiao S, Chen J, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B#, Wang H#  Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR-NF-kB signaling and protects from endotoxin shock. Immunity, 2014, 40: 501-514 (Cover Story)
22. Huang Y^*, Jiao S^*, Tao X, Tang Q#, Jiao W, Xiao J, Xu X, Zhang Y, Liang G, Wang H # Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation 2014,11:146;
23. Wei B^*, Han L*, Abbink T, Elisabetta G, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H# and Rudd CE#. Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology, 2013:10:101
24. Zhang Y and Wang H#. Integrin signaling and function in immune cells. Immunology, 2012;4(135):267-75
25. Li C^*, Xu X^*, Wang H# and Wei B#. PD-1 and CTLA-4 mediated inhibitory signaling for T cell exhaustion during chronic viral infections. Journal of Clinical & Cellular Immunology, 2012, S7-10.
26. Wang H#, Lim D and Rudd CE. Integrin signaling and immunopathology Semin Immunopathol 2010;32(2):173-82

作为第一作者发表的SCI文章：

27. Wang H, Lv Y and Rudd CE. SKAP1 is dispensable for chemokine induced T-cell migration Immunol Letters 2010:128(2):148-53.
28. Wang H, Wei B, Bismuth G, Rudd CE. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. PNAS 2009; 106(30):12436-41.
29. Wang H and Rudd CE. SKAP-55, SKAP-55Related and ADAP adaptors modulate integrin-mediated immune cell adhesion. Trends Cell Biol 2008; 18(10):486-93.   
30. Schenider H*, Wang H*, Raab M, Valk E, Smith X, Lovatt M, Wu, Z, Strebhardt K, Rudd CE. Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-Cells. PLoS ONE. 2008;5;3(3):e1718
31. Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007;27(19):6863-75  
32. Wang H, McCane F, Gordan J, Wu X, Raab M, Malik T, Davis D, Rudd CE. ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation. J. Exp. Med. 2004;200:1063-1074
33. Wang H*, Moon EY*, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol. 2003;4(4):366-74.

专利申请：

1.制备诊断败血症及重症细菌感染的诊断试剂（专利号201310548097.5    授权）

2．炎症相关肝癌的新型诊断和预后指标（申请号：201510430180.1   授权）

3. 成体干细胞体外培养方法及其应用 （申请号：201310205059    授权）

主要的受邀国际国内学术报告：

1. CMI 会议，合肥， 2021
2. 广东省免疫年77779193永利会，佛山，2021
3. 中国免疫学会基础免疫分会，济南，2021
4. 中国免疫学会临床免疫分会年77779193永利会，北京， 2021
5. 中国生物物理大会感染免疫分会，合肥，2021
6. 亚太地区免疫学课程（FIMSA），印度免疫学会主办，2020
7. 浙江省免疫学年77779193永利会，杭州，2020
8. 新加坡ASTAR，2019 & 新加坡国立大学，2019
9. 中国细胞生物学会，肿瘤代谢，南京，2019
10. 中国免疫学，基础免疫分会，海口，2019
11. 上海交通大学免疫学研究所，2019
12. 中国科技大学生科院，2019
13. 第二届国际免疫学论坛，南京，2018
14. 中国细胞生物学会，山会，贵州遵义，2018
15. 中国细胞生物学会，免疫分会，海宁，2018
16. Hippo国际会议，厦门大学，2018
17. 广东省免疫年77779193永利会和暨南大学免疫学会议，广州，2018
18. 山东省免疫学年77779193永利会，烟台，2018
19. 中国免疫学会青工委会议，武汉，2018
20. 苏州冷泉港会议，免疫、炎症和肿瘤，2017
21. 香港免疫学年77779193永利会，2017
22. The American Association of Immunologists (AAI) meeting, USA (May 2016)
23. The Chinese Biological Investigators Society (CBIS) meeting, Chengdu, China (Aug 2016)
24.  
25. JBC Editorial Member meeting, USA (April 2016)
26. 清华大学免疫研究所，2016
27. The Sixth Xiamen Winter Symposium, Xiamen, China (Dec 2015)
28. 香山会议, shanghai, China (Nov2015)
29. 第263届东方论坛会议 Shanghai, China (Oct 2015)
30. 中国科协第295次青年77779193永利科学家论坛会议, Nanjing, China (Nov 2015)
31. Cross straight immunology conference, Shandong, China (Oct 2015) 
32. ECI,  Austria (Sept 2015)
33. Cold Spring Harbor meeting, USA (April 2014)
34. 2014 Beijing-Shanghai Immunology Joint Symposium (April 2014)
35. The 12^th Cross-Strait Symposium on Biomedical Research, Shanghai (Sept 2013, Section Chair)
36. The 11th Cross-Strait Symposium on Biomedical Research, Taiwan (June 2012)
37. 4^th Sino‐Finn Life Science Forum, Finland (August 2011)
38. 14th International Congress of Immunology, Kobe, Japan (2010)

39. 博后或博士期间的受邀讲座：

40. . Cambridge Institute for Medical Research retreat, Wellcome Trust Center, Cambridge, UK (2009)
41. European Immunology Congress, Berlin, Germany (Sept. 2009)
42. Keystone meeting ‘Lymphocyte activation and signaling’, Snowbird, USA (2008)
43. Genetic control of T cell activation 2005 (Lofoten, Oslo, Norway)
44. 2002 British Society of Immunology (BSI), UK