“藏药现代化与独一味新药创制、资源保护及产业化示范”获国家科技进步奖二等（2015-J-234-2-04，10/10），“基于拼合原理的新型鬼臼毒素类抗癌药物的发现及作用机制研究”获甘肃省科技进步奖二等（2019-J2-030，1/10），“脱氧鬼臼毒素类抗癌药物的发现及作用机制研究”获甘肃医学科技奖一等（2018-1-5，1/6），“基于桃儿七提取物鬼臼毒素的药物研究”获甘肃药学发展奖二等（2013-Y2-06，1/5）。

论文专利

[1]Xing-Rong Wang, Shuai Wang, Wen-Bo Li, Kai-Yan Xu, Xue-Peng Qiao, Xue-Li Jing, Zi-Xiao Wang, Chang-jiang Yang, Shi-Wu Chen*. Design, synthesis and biological evaluation of novel 2-(4-(1H-indazol-6-yl)-1H-pyrazol-1-yl)acetamide derivatives as potent VEGFR-2 inhibitors, Eur. J. Med. Chem. 2021, 213, 113192.

[2]Shu-Yi Hao1, Zhi-Yuan Qi1, Shuai Wang, Xing-Rong Wang, Shi-Wu Chen*. Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects. Bioorg. Med. Chem. 2021, 29, 115985.

[3]Wen-Bo Li, Xue-Peng Qiao, Zi-Xiao Wang, Shuai Wang, Shi-Wu Chen*. Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin. Bioorg. Chem. 2020, 105, 104427.

[4]Xiu-Juan Zhang, Yu Xu, Hong-Xia Mou, Shuai Wang, Shu-Yi Hao, Shi-Wu Chen*. The synthesis and anti‐tumour properties of novel 4-substituted phthalazinones as Aurora B kinase inhibitors. Bioorg. Med. Chem. Lett. 2020, 30, 127556.

[5]Yu Xu1, Xiu-Juan Zhang1, Wen-Bo Li, Xing-Rong Wang, Xue-Peng Qiao, Shi-Wu Chen*. Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors. Eur. J. Med. Chem. 2020, 208, 112780.

[6]Zhi-Yuan Qi?, Shu-Yi Hao?, Heng-Zhi Tian, Hong-Li Bian, Ling Hui, Shi-Wu Chen*. Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives as tubulin polymerization inhibitors. Bioorg. Chem. 2020, 94, 103392.

[7]Yong-Xin Bo?, Rong Xiang?, Yu Xu, Shu-Yi Hao, Xing-Rong Wang, Shi-Wu Chen*. Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors. Bioorg. Med. Chem. 2020, 28 (5), 115351.

[8]Yu Xu, Shu-Yi Hao, Xiu-Juan Zhang, Wen-Bo Li, Xue-Peng Qiao, Zi-Xiao Wang, Shi-Wu Chen*. Development of novel 2,4-disubstituted pyrimidine derivatives as Aurora kinase inhibitors. Bioorg. Med. Chem. Lett. 2020, 30 (3), 126885.

[9]Shu-Yi Hao, Shi-Liang Feng, Xing-Rong Wang, Zhichao Wang, Shi-Wu Chen*, Ling Hui**. Novel conjugates of podophyllotoxin and coumarin: Synthesis, Cytotoxities, Cell cycle arrest and Inhibition of TOPO-Ⅱβ. Bioorg. Med. Chem. Lett. 2019, 29 (16), 2129–2135.

[10]You-Zhen Ma, Zhen-Bo Tang, Chun-Yan Sang, Zhi-Yuan Qi, Ling Hui, Shi-Wu Chen*. Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors. Bioorg. Med. Chem. Lett. 2019, 29 (5), 694–699.

[11]Chun-Yan Sang, Wen-Wen Qin, Xiu-Juan Zhang, Yu Xu, You-Zhen Ma, Xing-Rong Wang, Ling Hui, Shi-Wu Chen*. Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors. Bioorg. Med. Chem. 2019, 27 (1), 65–78.

[12]You-Zhen Ma, Zhen-Bo Tang, Chun-Yan Sang, Zhi-Yuan Qi, Ling Hui, Shi-Wu Chen*. Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors. Bioorg. Med. Chem. Lett. 2019, 29 (5), 694–699.

[13]Wei Wang, Xiu Feng, Huan-Xiang Liu, Shi-Wu Chen*, Ling Hui. Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors. Bioorg. Med. Chem. 2018, 26 (13), 3217–3226.

[14]Chun-Yan Sang, Heng-Zhi Tian, Yue Chen, Jian-Fei Liu, Shi-Wu Chen*, Ling Hui. Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4′-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors. Bioorg. Med. Chem. Lett. 2018, 28 (2), 71–76.

[15]Xiao-Hui Xu, Xiao-Wen Guan, Shi-Liang Feng, You-Zhen Ma, Shi-Wu Chen*, Ling Hui*. One-pot synthesis and biological evaluation of N-(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents. Bioorg. Med. Chem. Lett. 2017, 27(13), 2890–2894.

[16]Zhen-Bo Tang, Yao-Zhang Chen, Jie Zhao, Xiao-Wen Guan, Yong-Xin Bo, Shi-Wu Chen*, Ling Hui* Conjugates of podophyllotoxin and norcantharidin as dual inhibitors of topoisomeraseⅡ and protein phosphatase 2A. Eur. J. Med. Chem. 2016, 123, 568–576.

[17]Xiao-Wen Guan, Xiao-Hui Xu, Shi-Liang Feng, Zhen-Bo Tang, Shi-Wu Chen*, Ling Hui Synthesis of hybrid 4-deoxypodophyllotoxin–5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest. Bioorg. Med. Chem. Lett. 2016, 26(6), 1561–1566.

[18]Ling Hui*, Chun-Yan Sang, Dong-Hong Wang, Xiao-Hui Wang, Mei-Liang Wang, Qing-Hua Jia, Ming-Ren Ma, Shi-Wu Chen* Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro. Molecular Medicine Reports, 2016. 13: 339–346.

[19]Wen-Wen Qin, Chun-Yan Sang, Lin-Lin Zhang, Wei Wei, Heng-Zhi Tian, Huan-Xiang Liu, Shi-Wu Chen*, Ling Hui* Synthesis and biological evaluation of 2,4-diaminepyrimides as selective Aurora A kinase inhibitors. Eur. J. Med. Chem. 2015, 95, 174–184.

[20]Jie Zhao, Xiao-Wen Guan, Shi-Wu Chen*, Ling Hui Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25(2), 363–366.

发明专利：

1.陈世武，田瑄和涂永强，鬼臼脂素类化合物及其应用与制备方法，中国发明专利：ZL2004 1 **.3.

2.Dan Yang, Cheng-Yong Li and Shi-Wu Chen. 5-Demethoxyfumagillol and derivatives thereof. US Patent, US899067 B2.

3.陈世武，惠玲和金岩，一种脱氧鬼臼毒素类化合物及其制备与应用，中国发明专利：1.3.

4.陈世武，向蓉和惠玲，一种脱氧鬼臼与5-氟尿嘧啶的拼合物及其制备与应用，中国发明专利：5.5.

5.陈世武，赵杰和惠玲，一种鬼臼毒素与去甲斑蝥素的拼合物及其制备与应用，中国发明专利， ZL5.2（公告号CNB）

6.陈世武，孛永鑫，一种3,5-二取代的二氨基吡嗪化合物及其制备工艺与应用，中国发明专利：ZL7.3（公告号CNB）

7.陈世武，王维 一种肽嗪酮化合物及其制备与应用 中国发明专利 ZL1.3（申请日期：2018.03.15）（2020.12.29授权）(公告号CNA)

【主讲课程】 本科生：分析化学（2014年77779193永利获甘肃省精品课程称号）、药物合成反应；硕士生：药物研发概论。