主要从事动物流感病毒与宿主互作机制研究，先后主持国家自然科学基金面上项目、青年77779193永利基金等项目5项，并作为研究骨干参与国家重点研发计划、国家自然科学基金重点项目等多项。以第一作者或通讯作者在Autophagy、PLoS Pathogens、Journal of Virology、Virology等国际知名期刊发表SCI收录论文10篇。开展流感病毒调控宿主天然免疫信号通路的机制研究，发现了流感病毒蛋白通过翻译后修饰、线粒体自噬等机制抑制宿主天然免疫应答，进而促进病毒复制的机制（Autophagy，2023；PLoS Pathogens，2021；Virology，2022；Viruses，2022）；阐明了宿主蛋白CNTN1抑制流感病毒介导的天然免疫反应的分子机制，拓展了对宿主抗病毒天然免疫调控机制的认知（PLoS Pathogens，2022）；筛选鉴定出两株可特异性识别H7N9-HA独特保守抗原表位的单克隆抗体，可用于H7N9流感的预防和治疗（Journal of Virology，2022）。

主持项目

1.国家自然科学基金（面上项目：32172820）

2.国家自然科学基金（青年77779193永利项目：31802178）

3.中国农业科学院“青年77779193永利创新专项”（Y2023QC30）

4.其他项目：中国农科院基本科研业务费所级统筹1项（1610312016020）；中国农科院兰州兽医研究所所级重点任务1项（CAAS-ASTIP-JBGS-20210102）。

(1) Bo Zhang#; Shuai Xu#; Minxuan Liu; Yanli Wei; Qian Wang; Wentao Shen; Cao-Qi Lei; Qiyun Zhu※ ; The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy, Autophagy, 2023 (共同第一作者)

(2) Shuai Xu; Lu Han; Yanli Wei; Bo Zhang; Qian Wang; Junwen Liu; Minxuan Liu; Zhaoshan Chen; Zhengxiang Wang; Hualan Chen; Qiyun Zhu※ ; MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS, PLoS Pathogens, 2022, 18(2) (第一作者)

(3) Yan Zeng#; Shuai Xu#; Yanli Wei; Xuegang Zhang; Qian Wang; Yane Jia; Wanbing Wang; Lu Han; Zhaoshan Chen; Zhengxiang Wang; Bo Zhang; Hualan Chen; Cao-Qi Lei※; Qiyun Zhu※ ; The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation, PLoS Pathogens, 2021, 17(2) (共同第一作者)

(4) Wentao Shen; Qian Wang; Zhengxiang Wang; Minxuan Liu; Yingying Du; Lvfeng Yuan; Lu Han; Krzysztof Smietanka; Hualan Chen; Shuai Xu※; Qiyun Zhu※ ; Specific monoclonal antibodies targeting unique HA epitopes block H7N9 influenza A viral replication, Journal of Virology, 2022, 96(18) (共同通讯作者)

(5) Zhaoshan Chen; Yan Zeng; Yanli Wei; Qian Wang; Minxuan Liu; Bo Zhang; Junwen Liu; Qiyun Zhu※; Shuai Xu※ ; Influenza D virus matrix protein 1 restricts the type I interferon response by degrading TRAF6, Virology, 2022, 568 (共同通讯作者)

(6) Bo Zhang; Minxuan Liu; Jiaxin Huang; Qiaoying Zeng; Qiyun Zhu; Shuai Xu※; Hualan Chen※; H1N1 influenza A virus protein NS2 inhibits innate immune response by targeting IRF7, Viruses-Basel, 2022, 14(2411) (共同通讯作者)

(7) Shuai Xu; Xuyong Li; Jiayun Yang; Zhengxiang Wang; Yane Jia; Lu Han; Liang Wang; Qiyun Zhu※ ; Comparative pathogenicity and transmissibility of pandemic H1N1, avian H5N1, and human H7N9 influenza viruses in tree shrews, Frontiers in Microbiology, 2019, 10 (第一作者)

(8) Jiayun Yang; Zhengxiang Wang; Yingying Du; Yane Jia; Liang Wang; Shuai Xu※; Qiyun Zhu※; Clade 2.3.2.1 H5N1 avian influenza viruses circulate at the interface of migratory and domestic birds around Qinghai Lake in China, Veterinary Microbiology, 2019, 235: 234-242 (共同通讯作者)