中国农业科学院“青年77779193永利英才计划”院级入选者，兰州兽医研究所“元亨人才”特聘研究员，研究生导师。2005年77779193永利于河南科技学院获农学学士学位，2008年77779193永利于新疆农业大学获农学硕士学位，2015年77779193永利于法国南特大西洋国立兽医大学（ONIRIS）获生物学博士学位。2008年77779193永利-至今在中国农业科学院兰州兽医研究所外寄生虫与虫媒疫病创新团队从事虫媒及虫媒疫病研究工作。2017年77779193永利3月-2019年77779193永利6月于美国德克萨斯大学医学部（UTMB）微生物与免疫学中心从事博士后工作。至今在J Clin Invest、PLoS Pathogens、J Immunol、J Virol、Front immunol等国际主流期刊发表SCI论文60余篇；在国内核心期刊发表论文40余篇；获授权专利15项。现任美国免疫学协会会员、国家自然科学基金评议专家、教育部学位中心论文评审专家；FRONT MICROBIOL副主编；EMERG MICROBES INFEC; VIRUSES; PATHOGENS; PLOS NEGLECT TROP D; INFECT GENET EVOL; VET PARASITOL; PARASITE VECTOR; PARASITOL RES等杂志评审专家。

研究领域与方向：

现主要从事非洲猪瘟病原与流行病学、表观遗传分子调控病毒复制及致病机制、非洲猪瘟防控技术研发等方面的研究。

主要科研项目（主持/负责人）：

十四五国家重点研发计划子课题（经费160万，2021-2025）

甘肃省科技重大专项项目（经费300万，2021-2024）

国家自然科学基金面上项目（经费58万，2021-2024）

青年77779193永利英才计划人才启动项目（经费200万，2020-2024）

中央事业单位基本科研业务费（经费30万，2021-2023）

家畜疫病病原生物学国家重点实验室重大成果培育项目（100万，2020-2025）

国家自然科学基金青年77779193永利项目（经费24万元，2016-2018）

甘肃省自然科学基金青年77779193永利项目（经费2万元，2010-2012）

论文发表：

1. Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest, 2019;129(8):3361-3373. IF: 12.282

2. Fan J, Lv XQ, Yang SX, Geng SX, Yang J, Niu Q et al. OGG1 inhibition suppresses African swine fever virus replication. Virol Sin, 2023;38(1):96-107. IF:6.947 (并通讯)

3. Zhao YR, Niu Q, Yang SX, Yang, JF, Zhang ZH, et al. Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection. Microbiol Spectr, IF: 9.043. (并第一，并通讯)

4. Sun H, Niu Q, Yang, JF, Zhao YR, Tian ZZ, Fan, J, et al. Transcriptome Profiling Reveals Features of Immune Response and Metabolism of Acutely Infected, Dead and Asymptomatic Infection of African Swine Fever Viruses in Pigs. Front immunol. IF: 7.561. (并列通讯)

5. Auclair S, Liu F, Niu Q, Hou W, Churchyard G et al. Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. PloS Pathog, 2018; 14: e1006888. IF: 6.158

6. Liu F, Niu Q, Fan X, Liu C,Zhang J,Wei Z et al. Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. J Immunol, 2017; 199: 3293-3305. IF: 4.539

7. Niu Q, Yang J, Liu Z, Gao S, Pan Y, Guan G, et al. First molecular detection of piroplasm infection in pet dogs from Gansu, China. Front Microbiol, 2017; 8:1029. IF: 4.019

8. Niu Q, Liu Z, Yang J, Gao S, Pan Y, Guan G, et al. Genetic characterization and molecular survey of Babesia sp. Xinjiang infection in small ruminants and ixodid ticks in China. Infect Genet Evol. 2017; 49: 330-335. IF: 2.88

9. Niu Q, Guan G, Liu Z, Yang J, Yu P, Pan Y, et al. Molecular cloning, characterization and antigenicity of Babesia sp. BQ1 (Lintan) (Babesia cf. motasi) apical membrane antigen-1 (AMA-1). Parasitology, 2017; 144(5):641-649. IF: 2.511

10. Niu Q, Liu Z, Yang J, Yu P, Pan Y, Zhai B, et al. Expression analysis and biological characterization of Babesia sp. BQ1 (Lintan) (Babesia motasi-like) rhoptry-associated protein 1 and its potential use in serodiagnosis via ELISA. Parasit & Vectors, 2016; 9:313. IF: 3.234

11. Niu Q, Liu Z, Yang J, Yu P, Pan Y, Zhai B, et al. Genetic diversity and molecular characterization of Babesia motasi-like in small ruminants and ixodid ticks from China. Infect Genet Evol, 2016; 41:8-15. IF: 2.591

12. Niu Q, Liu Z, Yang J, Yu P, Pan Y, Zhai B, et al. Expression of sheep pathogen Babesia sp. Xinjiang rhoptry associated protein 1 and evaluation of its diagnostic potential by enzyme-linked immunosorbent assay. Parasitology, 2016, 143:1990-1999. IF: 3.031

13. Niu Q, Bonsergent C, Rogniaux H, Guan G, Malandrin L, Moreau E. RAP-1a is the main rhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesia sp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep in China. Vet Parasitol, 2016, 232:48-57. IF: 2.545

14. Yu P*, Niu Q*, Liu Z, Yang J, Chen Z, Guan G, et al. Using molecular epidemiological surveillance to assess the emergence and re-emergence of tick-borne infections in China. Acta Trop, 2016, 158: 181-188. IF: 2.38

15. Omar Abdallah M*, Niu Q*, Yu P, Guan G, Yang J, Chen Z, et al. Identification of piroplasm infection by RLB in questing tick species of China: A broad range extension of tick-borne piroplasm in China? Parasitol Res, 2016,115: 2035-2044. IF:2.558

16. Niu Q, Liu Z, Yu P, Yang J, Omar Abdallah M, Guan G, et al. Genetic characterization and molecular survey of Babesia bovis, Babesia bigemina and Babesia ovata in cattle, dairy cattle and yaks in China. Parasit & Vectors, 2015, 8:518. IF: 3.43

17. Niu Q, Marchand J, Yang C, Bonsergent C, Guan G, Yin H, Malandrin L. Rhoptry-associated protein (rap-1) genes in the sheep pathogen Babesia sp. Xinjiang: Multiple transcribed copies differing by 3’ end repeated sequences. Vet Parasitol, 2015, 211: 158-69. IF: 2.46

18. Niu Q, Valentin C, Bonsergent C, Malandrin L. Strong conservation of rhoptry-associated-protein-1 (RAP-1) locus organization and sequence among Babesia isolates infecting sheep from China (Babesia motasi-like phylogenetic group). Inf Gen Evol, 2014, 28: 21-32. IF: 3.015

19. Niu Q, Bonsergent C, Guan G, Yin H, Malandrin L. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group). Vet Parasitol, 2013, 198: 24-38. IF: 2.545

20. Niu Q, Guan G, Liu Z, Ma M, Li Y, Liu A, et al. Simultaneous detection of piroplasma infections in field Haemaphysalis qinghaiensis ticks by reverse line blotting. Exp Appl Acarol, 2012, 56:123-32. IF 1.847

21. Niu Q, Luo J, Guan G, Liu Z, Ma M, Liu A, et al. Differentiation of two ovine Babesia based on the ribosomal DNA internal transcribed spacer (ITS) sequences. Exp Parasitol , 2009, 121: 64-8. IF: 1.773

22. Niu Q, Luo J, Guan G, Ma M, Liu Z, Liu A, et al. Detection and differentiation of ovine Theileria and Babesia by reverse line blotting in China, Parasitol Res, 2009, 104:1417-23. IF:1.721

23. Guan G, Niu Q, Yang J, Li Y, Gao J, Luo J, et al. Trypanosoma (Herpetosoma) grosi: first isolation from Chinese striped field mouse (Apodemus agrarius). Parasitol Int, 2011, 60:101-4. IF:2.055

24. Abdallah MO, Niu Q, Yang J, Hassan MA, Yu P , Guan G, et al. Identification of 12 Piroplasms Infecting Ten Tick Species in China Using Reverse Line Blot Hybridization. J Parasitol, 2017, 103: 221-227. IF: 1.395

25. Yang J, Liu Z, Niu Q, Mukhtar MU, Guan G, et al. A novel genotype of "Anaplasma capra" in wildlife and its phylogenetic relationship with the human genotypes. Emerg Microbes Infect, 2018, 7:210. IF: 6.032

26. Han R, Yang J, Niu Q, Liu Z, Chen Z, et al. Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. Infect Genet Evol, 2018, 57:1-7. IF: 2.545

27. Yang J, Han R, Niu Q, Liu Z, Guan G, et al. Occurrence of four Anaplasma species with veterinary and public health significance in sheep, northwestern China. Ticks Tick Borne Dis, 2018, 9:82-85. IF:2.612

28. Yu P, Liu Z, Niu Q, Yang J, Abdallah MO, et al. Molecular evidence of tick-borne pathogens in Hyalomma anatolicum ticks infesting cattle in Xinjiang Uygur Autonomous Region, Northwestern China. Exp Appl Acarol. 2017,73:269-281. IF:1.929

29. Yang J, Liu Z, Niu Q, Liu J, Han R, et al. A novel zoonotic Anaplasma species is prevalent in small ruminants: potential public health implications. Parasit Vectors, 2017, 10:264. IF: 3.163

30. Wang Z, Yang J, Niu Q, Brayton KA, Luo J, et al. Identification of Anaplasma ovis appendage-associated protein (AAAP) for development of an indirect ELISA and its application. Parasit Vectors, 2017, 10:359. IF: 3.163

31. Yang J, Liu Z, Niu Q, Luo J, Wang X, et al. Molecular Detection of Anaplasma phagocytophilum in Wild Cervids and Hares in China. J Wildl Dis, 2017, 53:420-423. IF: 1.247

32. Yang J, Guan G, Niu Q, Liu Z, Li Y, Liu J, et al. Development and application of a loop-mediated isothermal amplification assay for rapid detection of Borrelia burgdorferi s. l. in ticks, 2013, 60: 238-44. IF:3.504

33. Alamer E, Zhong C, Liu Z, Niu Q, Long F, et al. Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. J Virol, 2020, 94:e01880-19. IF: 4.501

34. Iqbal N, Mukhtar MU, Yang J, Niu Q, Li Z, et al. Identification and evaluation of midgut protein RL12 of Dermacentor silvarum interacting with Anaplasma ovis VirD4. Ticks Tick Borne Dis, 2021, 12:101677. IF: 3.744

授权专利：

1. 牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物ARV-825用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684043.1

2. 牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物I-BET-762用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684033.8

3. 牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物PLX51107用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684339.3

4. 牛庆丽，杨吉飞，赵亚茹，刘志杰，关贵全，罗建勋，殷宏，化合物ZL0580用于制备预防或治疗非洲猪瘟药物的新用途。2021.06.08，中国，ZL202010684287.X

5. 牛庆丽，刘志杰，杨吉飞，潘玉萍，关贵全，罗建勋，殷宏，羊新疆巴贝斯虫未定种的诊断试剂盒及检测方法。2020.02.18，中国，ZL201610905860.9

6. 牛庆丽，刘志杰，杨吉飞，关贵全，李有全，殷宏，罗建勋，一种用于羊新疆巴贝斯虫病检测的间接ELISA方法。 2018.10.16，中国，ZL201610890348.1

7. 王锦明，关贵全，牛庆丽，刘军龙，任巧云，李有全，刘爱红，刘志杰，殷宏，罗建勋，刘光远，杨吉飞，陈泽，田占成，一种可用于羊泰勒虫检测的引物及试剂盒。2022.5.27，中国，ZL201910296143.4

8. 刘志杰，赵亚茹，杨吉飞，牛庆丽，刘光远，罗建勋，关贵全，殷宏，抗非洲猪瘟病毒P30蛋白单域抗体和检测非洲猪瘟病毒的ELISA试剂盒。2021.03.30，中国，ZL201910972470.7

9. 刘志杰，殷宏，赵亚茹，杨吉飞，牛庆丽，刘光远，罗建勋，关贵全，抗非洲猪瘟病毒K205R蛋白单克隆抗体的杂交瘤细胞株及其分泌的抗体。2021.09.17，中国，ZL201910048598.4

10. 刘志杰，殷宏，王振国，杨吉飞，牛庆丽，罗建勋，关贵全，一种重组蛋白P35的制备方法。2021.06.15，中国，ZL201810375550.X

11. 刘爱红，关贵全，刘军龙，谢俊仁，牛庆丽，罗建勋，殷宏, 一种检测羊巴贝斯虫的实时荧光定量PCR试剂盒。 2017.10.31, 中国，ZL201510011313.1.

学术荣誉：

（1）2022年77779193永利甘肃省自然科学奖二等奖（第二完成人）

（2）中国农科院农科英才

（3）美国免疫学协会会员

（4）国家自然科学基金评议专家、

（5）教育部学位中心论文评审专家；

（6）FRONT MICROBIOL副主编；

（7）EMERG MICROBES INFEC; VIRUSES; PATHOGENS; PLOS NEGLECT TROP D; INFECT GENET EVOL; VET PARASITOL; PARASITE VECTOR; PARASITOL RES等杂志评审专家。

专业证书

美国生物安全二级认证证书和美国动物生物安全二级认证证书 （国际生物安全培训中心）

专著

参译《骆驼传染病》中国科学技术出版社，ISBN：9787511624345,2016-12-01.

国际学术交流：

曾参加在美国、法国、意大利和土耳其举办的关于病毒、虫媒病和影响全球健康的新发及再发流行病学国际学术会议，并受邀作大会报告或海报。

口头报告：

1. The Rhoptry-Associated-Protein 1 locus in the sheep parasite Babesia sp. BQ1 (Lintan) Many conserved features with B. bigemina. 2013. 10. Turkey

2. Babesiosis of small ruminants: Evaluation of Rhoptry-Associated-Protein-1 (RAP-1) as a vaccine candidate. 2012.11. Clermont, Saint-Gènes-Champanelle, France

会议海报：

1. Niu Q, Liu Z, Alamer E, Fan X, et al. A novel small molecule modulating BRD4 and transcription elongation to epigenetically suppress HIV. 2019, Galveston, USA

2.  Niu Q, Moreau E, Chauvin A, Malandrin L. Babesiosis of small ruminants: evaluation of the Rhoptry-associated-protein RAP-1 as a vaccine candidate. 2011.11. Talmont St Hilaire, France

3. Niu Q, Bonsergent C, Moreau E, Guan G, Yin H, Malandrin L. Babesia sp. BQ1 Lintan (B. motasi group) rap-1 locus. A target to vaccine development. 2012. Orvietto, Italy

4. Niu Q, Marchand J, Bonsergent C, Congshan Y, Guan G, Yin H, Malandrin L. The rhoptry-associated-protein 1 family in the sheep parasite Babesia sp. Xinjiang. 2013. Turkey

人才培养：

培养（协助培养）博士、硕士研究生，合计14名